Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Samar Alsafadi, Alexandre Houy, Aude Battistella, +9

Nature Communications

Tumor BiologyCancer-associated Sf3b1 MutationsSomatic VariantMedicineGenetics +7

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

Lynn Quek, Muriel D. David, Alison Kennedy, +22

Nature Medicine

Hematological MalignancyClonal HeterogeneityMedicineAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +9

Targeting the Deregulated Spliceosome Core Machinery in Cancer Cells Triggers mTOR Blockade and Autophagy

Virginie Quidville, Samar Alsafadi, Aïcha Goubar, +14

Cancer Research

Cancer Cells TriggersCell DeathCancer BiologyTumor BiologyCell Autophagy +14

Splicing Patterns in <i>SF3B1</i> -Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes

Jérémy Bigot, Ana I. Lalanne, Francesca Lucibello, +22

Cancer Discovery

A variant erythroferrone disrupts iron homeostasis in <i>SF3B1</i> -mutated myelodysplastic syndrome

Sabrina Bondu, Anne‐Sophie Alary, Carine Lefèvre, +36

Science Translational Medicine

Germline <i>MBD4</i> Mutations and Predisposition to Uveal Melanoma

Anne‐Céline Derrien, Manuel Rodrigues, Alexandre Eeckhoutte, +14

JNCI Journal of the National Cancer Institute

Chk1 as a new therapeutic target in triple-negative breast cancer

Laurence Albigès, Aïcha Goubar, Véronique Scott, +10

The Breast

Evolutionary Routes in Metastatic Uveal Melanomas Depend on <i>MBD4</i> Alterations

Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, +21

Clinical Cancer Research

Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model

Giulia Fornabaio, Raymond L. Barnhill, Claire Lugassy, +5

Scientific Reports

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

Philip Bland, Harry Saville, Patty T. Wai, +36

Nature Genetics