Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin‐3

Sokol V. Todi, Brett J Winborn, K. Matthew Scaglione, +3

The EMBO Journal

Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

Sokol V. Todi, K. Matthew Scaglione, Jessica R. Blount, +5

Journal of Biological Chemistry

Molecular BiologyMany Ubiquitin-dependent PathwaysUbiquitin-binding SitesAutophagyDegenerative Pathology +15

Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23

Jessica R. Blount, Wei‐Ling Tsou, Gorica Ristic, +5

Nature Communications

Proteasomal DegradationProtein FunctionMolecular RegulationNatural SciencesMedicine +8

Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes

Wei‐Ling Tsou, Michael J. Sheedlo, Marie E. Morrow, +4

PLoS ONE

GeneticsGenomic MechanismMolecular GeneticsDrosophila MelanogasterDrosophila Development +14

Ubiquitin-Specific Protease 25 Functions in Endoplasmic Reticulum-Associated Degradation

Jessica R. Blount, Aaron A. Burr, Amanda Denuc, +2

PLoS ONE

Protein FunctionUbiquitin Ligase Hrd1Protein FoldingMedicineErad Substrates +10

Ubiquitination Regulates the Neuroprotective Function of the Deubiquitinase Ataxin-3 in Vivo

Wei‐Ling Tsou, Aaron A. Burr, Michelle Ouyang, +3

Journal of Biological Chemistry

Molecular RegulationProtein UbiquitinationMolecular BiologySynaptic SignalingDrosophila Melanogaster +17

The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster

Wei‐Ling Tsou, Michelle Ouyang, Ryan R. Hosking, +4

Neurobiology of Disease

Drosophila MelanogasterNatural SciencesGeneticsGenomic MechanismMolecular Biology +5

Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Joanna R. Sutton, Jessica R. Blount, Kozeta Libohova, +6

Human Molecular Genetics

Neurodegenerative DiseasesMolecular NeuroscienceProteasome Shuttle Rad23GeneticsAtaxin-3-rad23 Interaction +10

Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3

Sean L. Johnson, Jessica R. Blount, Kozeta Libohova, +4

Neurobiology of Disease

Fruit FlyDevelopmental BiologyMolecular NeuroscienceAtaxin-3 IsoformsGenetic Disorder +12

Drosophila as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

Sean L. Johnson, Matthew V. Prifti, Alyson Sujkowski, +5

Cells