MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.

Hans Rollema, M Skolnik, Jan C. d’Engelbronner, +3

Journal of Pharmacology and Experimental Therapeutics

CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Michael Zhuo Wang, Janelle Saulter, Etsuko Usuki, +13

Drug Metabolism and Disposition

Studies on the metabolism of haloperidol (HP): The role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP

Kazuei Igarashi, Fumiyo Kasuya, Miyoshi Fukui, +2

Life Sciences

Ip AdministrationBiochemistryMedicineNeuropharmacologyToxicology +9

Studies on the Conversion of Haloperidol and Its Tetrahydropyridine Dehydration Product to Potentially Neurotoxic Pyridinium Metabolites by Human Liver Microsomes

Etsuko Usuki, Robin E. Pearce, Andrew Parkinson, +1

Chemical Research in Toxicology

Human Cytochrome P450Toxicological MechanismOxidative StressToxicologyHepatotoxicity +17

Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression

Angelique M. Leone, L. Mark Kao, Michael McMillian, +7

Chemical Research in Toxicology

Valproic AcidPharmacological StudyBiochemistryMedicineDrug Discovery +12

Metabolic Studies on Haloperidol and Its Tetrahydropyridine Analog in C57BL/6 Mice

Cornelis J. Van der Schyf, Kay Castagnoli, Etsuko Usuki, +3

Chemical Research in Toxicology

Chronic Hp TreatmentOrganic ChemistryTetrahydropyridine AnalogToxicological MechanismNeuroleptic Agent Haloperidol +15

Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon

Kathryn M. Avent, Etsuko Usuki, Darryl W. Eyles, +4

Life Sciences

Neurotoxic Pyridinium SpeciesBioorganic ChemistryBiochemistryMedicineNatural Sciences +9

Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: Is HPTP an intermediate?

Kathryn M. Avent, Richard R. Riker, Gilles L. Fraser, +3

Life Sciences

BiochemistryMedicinePhysiologyHigh DosesToxicology +7

An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes

Alaa-Eldin F. Nassar, Ivan King, Brandy L. Paris, +8

Drug Metabolism and Disposition