Etsuko Usuki

MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.

Hans Rollema, M Skolnik, Jan C. d’Engelbronner et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 123 citations

Medicine, Neurobiology, Pharmacology +15

CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

Michael Zhuo Wang, Janelle Saulter, Etsuko Usuki et al. · Drug Metabolism and Disposition · 2006 · 92 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Studies on the Conversion of Haloperidol and Its Tetrahydropyridine Dehydration Product to Potentially Neurotoxic Pyridinium Metabolites by Human Liver Microsomes

Etsuko Usuki, Robin E. Pearce, Andrew Parkinson et al. · Chemical Research in Toxicology · 1996 · 66 citations

Medicine, Biochemistry, Pharmacology +17

Studies on the metabolism of haloperidol (HP): The role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP

Kazuei Igarashi, Fumiyo Kasuya, Miyoshi Fukui et al. · Life Sciences · 1995 · 66 citations

Medicine, Pharmacokinetics, Pharmacology +15

Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression

Angelique M. Leone, L. Mark Kao, Michael McMillian et al. · Chemical Research in Toxicology · 2007 · 62 citations

Medicine, Pharmacology, Toxicology +14