Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Nadine K. Kolas, J. Ross Chapman, Shinichiro Nakada, +10

Science

ChromatinGenome InstabilityUbiquitin Ligase Rnf8Ubiquitin ConjugationBreast Cancer Susceptibility +10

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

Grant S. Stewart, Stephanie Panier, Kelly Townsend, +17

Cell

ChromatinGenome InstabilityDna DamageChromatin RemodelingNatural Sciences +8

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Shinichiro Nakada, Ikue Tai, Stephanie Panier, +11

Nature

ChromatinGenome InstabilityMolecular BiologyNon-canonical InhibitionMedicine +1

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

Takaaki Yasuhara, Reona Kato, Yoshihiko Hagiwara, +5

Cell

Genome InstabilityTranscriptional RegulationHuman Rad52GeneticsXpg-mediated R-loop Processing +4

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, +23

Cell

ChromatinTranscriptional RegulationGenome InstabilityMedicineCell Biology +1

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint

Shinichiro Nakada, Ginny I. Chen, Anne‐Claude Gingras, +1

EMBO Reports

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

Hiroyuki Morisaka, Kazuto Yoshimi, Yuya Okuzaki, +12

Nature Communications

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

Mayu Isono, Atsuko Niimi, Takahiro Oike, +11

Cell Reports

RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

Shojiro Inano, Koichi Sato, Y Katsuki, +11

Molecular Cell

ChromatinGenome InstabilityDna DamageGeneticsMolecular Biology +7

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes

Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, +14

Proceedings of the National Academy of Sciences