Marc O’Reilly

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Barbara Chaneton, Petra Hillmann, Liang Zheng et al. · Nature · 2012 · 647 citations · Full text

Pyruvate Kinase M2, Natural Ligand, Signal Transduction +10

Identification of <i>N</i>-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1<i>H</i>-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Paul G. Wyatt, Andrew Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2008 · 337 citations · Full text

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Steven Howard, Valério Berdini, John A. Boulstridge et al. · Journal of Medicinal Chemistry · 2008 · 329 citations · Full text

Drug Target, Pyrazol-4-yl Urea, Clinical Candidate +18

Crystal structure of human CDK4 in complex with a D-type cyclin

Philip J. Day, Anne Cleasby, Ian J. Tickle et al. · Proceedings of the National Academy of Sciences · 2009 · 225 citations · Full text

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Adrian L. Gill, Martyn Frederickson, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 185 citations · Full text

Combinatorial Chemistry, Drug Target, Hit Identification +18