SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Matthew D. Figley, Weixi Gu, Jeffrey D. Nanson, +21

Neuron

Nmn/nad+ RatioMolecular NeuroscienceSignal TransductionMitochondrial FunctionMolecular Biology +9

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

Rupert J. Russell, Philip S. Kerry, David Stevens, +4

Proceedings of the National Academy of Sciences

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules

Yun Shi, Philip S. Kerry, Jeffrey D. Nanson, +22

Molecular Cell

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

Benjamin G. Hale, Philip S. Kerry, David Jackson, +5

Proceedings of the National Academy of Sciences

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

Santosh Rudrawar, Jeffrey C. Dyason, Marie‐Anne Rameix‐Welti, +7

Nature Communications

Development of a Selective Inhibitor of Protein Arginine Deiminase 2

Aaron Muth, Venkataraman Subramanian, Edward Beaumont, +7

Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryDrug TargetProtein ExpressionBiochemistry +13

A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain

Philip S. Kerry, Juan Ayllón, Margaret Taylor, +6

PLoS ONE

Ed Homodimeric ContactVirus StructureViral ReplicationEngineeringSynthetic Virology +11

Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor

Sankar Mohan, Philip S. Kerry, Nicole Bance, +2

Angewandte Chemie International Edition

Structural basis for a class of nanomolar influenza A neuraminidase inhibitors

Philip S. Kerry, Sankar Mohan, Rupert J. Russell, +3

Scientific Reports

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility

Santosh Rudrawar, Philip S. Kerry, Marie‐Anne Rameix‐Welti, +8

Organic & Biomolecular Chemistry

Virus StructureMedicinal ChemistryBiochemistryNatural SciencesDrug Discovery +13