Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Aaheli Roy Choudhury, Zhenyu Ju, Meta W. Djojosubroto, +13

Nature Genetics

Cancer FormationCdkn1a DeletionMedicineStem CellsStem Cell Research +10

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Jianwei Wang, Qian Sun, Yohei Morita, +17

Cell

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

Sarah Schwitalla, Paul K. Ziegler, David Horst, +13

Cancer Cell

Carcinogen-induced Colorectal TumorsMedicineBiological MicroenvironmentsColorectal CancerCell Death +8

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler, Anett Illing, Patrick Hermann, +25

Gut

Telomerase gene mutations are associated with cirrhosis formation

Daniel Hartmann, Ujala Srivastava, Michaela Thaler, +29

Hepatology

Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice

Sonja Schaetzlein, N.R. Kodandaramireddy, Zhenyu Ju, +13

Cell

Knockout MouseGenome InstabilityGene Deletion DataDna DamageGenetics +9

Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis†

Ruben R. Plentz, Young Nyun Park, André Lechel, +9

Hepatology

Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri

Nils Hartmann, Kathrin Reichwald, André Lechel, +9

Mechanisms of Ageing and Development

BiologyDevelopmental BiologyLongevityMolecular GeneticsTert Expression Increases +4

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Simon Schwörer, F Becker, Christian Feller, +17

Nature

Epigenetic Stress ResponsesChromatinLineage PlasticityDevelopmental BiologyMuscle Stem-cell Ageing +10

Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Ronan Russell, Lukas Perkhofer, Stefan Liebau, +15

Nature Communications