André Lechel

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Aaheli Roy Choudhury, Zhenyu Ju, Meta W. Djojosubroto et al. · Nature Genetics · 2006 · 418 citations

Cancer Formation, Cdkn1a Deletion, Medicine +12

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Jianwei Wang, Qian Sun, Yohei Morita et al. · Cell · 2012 · 337 citations · Full text

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

Sarah Schwitalla, Paul K. Ziegler, David Horst et al. · Cancer Cell · 2012 · 297 citations · Full text

Carcinogen-induced Colorectal Tumors, Medicine, Biological Microenvironments +10

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler, Anett Illing, Patrick Hermann et al. · Gut · 2016 · 209 citations · Full text

Telomerase gene mutations are associated with cirrhosis formation

Daniel Hartmann, Ujala Srivastava, Michaela Thaler et al. · Hepatology · 2011 · 170 citations · Full text