Christine E. Bear

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

Christine E. Bear, Canhui Li, Norbert Kartner et al. · Cell · 1992 · 943 citations

Protein Secretion, Fibrosis, Signal Transduction +11

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

Norbert Kartner, John W. Hanrahan, Tim Jensen et al. · Cell · 1991 · 499 citations

Regulated Anion Conductance, Cystic Fibrosis Gene, Fibrosis +11

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

Amy P. Wong, Christine E. Bear, Stephanie Chin et al. · Nature Biotechnology · 2012 · 424 citations · Full text

Induced Pluripotent Stem Cell, Developmental Biology, Directed Differentiation +10

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

Richard Rozmahe, Michael Wilschanski, Angabin Matin et al. · Nature Genetics · 1996 · 387 citations

Knockout Mouse, Disease Susceptibility, Molecular Physiology +11

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

Gergely L. Lukács, X.B. Chang, Christine E. Bear et al. · Journal of Biological Chemistry · 1993 · 386 citations · Full text