Thomas Nixey

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Yuan Cheng, Ted Judd, Michael D. Bartberger et al. · Journal of Medicinal Chemistry · 2011 · 136 citations · Full text

Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline

Adrian L. Smith, Frenel DeMorin, Nick A. Paras et al. · Journal of Medicinal Chemistry · 2009 · 103 citations · Full text

Aminoisoquinoline Core, Selective Inhibitors, Pharmacotherapy +16

Novel Vanilloid Receptor-1 Antagonists:  2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Elizabeth M. Doherty, Christopher Fotsch, Anthony W. Bannon et al. · Journal of Medicinal Chemistry · 2007 · 98 citations · Full text

Fragment Based Drug Discovery: Practical Implementation Based on ¹⁹F NMR Spectroscopy

John B. Jordan, Leszek Poppe, Xiaoyang Xia et al. · Journal of Medicinal Chemistry · 2011 · 81 citations · Full text

The one-pot solution phase preparation of fused tetrazole-ketopiperazines

Thomas Nixey, Michael Kelly, Christopher Hulme · Tetrahedron Letters · 2000 · 76 citations

Organic Chemistry, Fused Tetrazole-ketopiperazines, Synthesis Method +1