Lukas D. Osborne

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Christophe Guilluy, Lukas D. Osborne, Laurianne Van Landeghem et al. · Nature Cell Biology · 2014 · 575 citations · Full text

Mechanobiology, Nuclei Adapt, Developmental Biology +14

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Sara C. Hanna, Bhavani Krishnan, Sean T. Bailey et al. · Journal of Clinical Investigation · 2013 · 144 citations · Full text

Cancer Research, Transcriptional Regulation, Oncology +14

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells

Caitlin Collins, Lukas D. Osborne, Christophe Guilluy et al. · Nature Communications · 2014 · 111 citations · Full text

Mechanobiology, Engineering, Mechanical Phenotype +15

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion

Lukas D. Osborne, George Z. Li, Tam How et al. · Molecular Biology of the Cell · 2014 · 60 citations · Full text

Tgf-β Regulates Larg, Cell Adhesion, Cytoskeleton +22

The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1–Dependent Mechanotransduction in Endothelial Cells To Stimulate Transendothelial Migration

Elizabeth C. Lessey-Morillon, Lukas D. Osborne, Elizabeth Monaghan-Benson et al. · The Journal of Immunology · 2014 · 57 citations · Full text

Endothelial Cells, Cell Adhesion, Immunology +22