Kazutaka Higaki

Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs

Jun-ichi Jinno, Naoki Kamada, Masateru Miyake et al. · Journal of Controlled Release · 2006 · 503 citations

Poorly Water-soluble Drug, Particle Size Reduction, Pharmacological Study +4

Establishment of new preparation method for solid dispersion formulation of tacrolimus

Kazunari Yamashita, Toshiomi Nakate, Kazuto Okimoto et al. · International Journal of Pharmaceutics · 2003 · 340 citations

Biomedical Engineering, New Preparation Method, Pharmaceutical Technology +1

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics

Susumu Nagayama, Ken‐ichi Ogawara, Yoshiko Fukuoka et al. · International Journal of Pharmaceutics · 2007 · 223 citations

Nanomedicine, Opsonin Amount, Time-dependent Changes +12

Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles

Ken‐ichi Ogawara, Kentaro Furumoto, Susumu Nagayama et al. · Journal of Controlled Release · 2004 · 192 citations

Nanoparticles, Nanomedicine, Engineering +10

[Niemann-Pick disease [type A and B] (acid sphingomyelinase deficiencies)].

Kazutaka Higaki, K Ohno · PubMed · 1998 · 172 citations

Mendelian Disorder, Disease Mechanism, Acid Sphingomyelinase Deficiencies +9