Brad A. Acker

Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Daniel P. Walker, Donn G. Wishka, David W. Piotrowski et al. · Bioorganic & Medicinal Chemistry · 2006 · 94 citations

Structure–activity Relationship, Vivo Activity, Biochemistry +8

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

Brad A. Acker, E. Jon Jacobsen, Bruce N. Rogers et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 60 citations · Full text

Molecular Pharmacology, Vivo Activity, Biochemistry +7

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Michael B. Tollefson, Brad A. Acker, E. Jon Jacobsen et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +7

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Dafydd R. Owen, John K. Walker, E. Jon Jacobsen et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 23 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +8

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Robert Hughes, John K. Walker, Jerry W. Cubbage et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 19 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Central Ring System +11