GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang, +43

Journal of Medicinal Chemistry

Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc

Yu Zhong, Liting Yang, Fang Xiong, +17

Signal Transduction and Targeted Therapy

Diagnostic accuracy of sub-mSv prospective ECG-triggering cardiac CT in young infant with complex congenital heart disease

Wei Gao, Yu Zhong, Ai Min Sun, +6

International journal of cardiac imaging

Health SciencesMedical ImagingPediatric Heart DiseasePediatricsDiagnosis +8

Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang, +29

ACS Medicinal Chemistry Letters

m6AmPred: Identifying RNA N6, 2′-O-dimethyladenosine (m6Am) sites based on sequence-derived information

Jie Jiang, Bowen Song, Kunqi Chen, +4

Methods

Sequence MotifSequence-derived InformationFunctional GenomicsRna N6Structural Bioinformatics +9

Integrating physiological and transcriptome analyses clarified the molecular regulation mechanism of PyWRKY48 in poplar under cadmium stress

Xiaolu Wu, Lulu Chen, Xinyi Lin, +10

International Journal of Biological Macromolecules

BiologyPlant Molecular BiologyBiosynthesisEngineeringPlant Stress +9

Identification of prognosis-related hub genes of ovarian cancer through bioinformatics analyses and experimental verification

Yu Zhong, Ling Ouyang

Medicine

Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha

Birong Zhang, James R. Kiefer, Robert A. Blake, +20

Bioorganic & Medicinal Chemistry Letters

Co-crystal StructuresMedicinal ChemistryNatural SciencesHormonal ReceptorEquivalent Potency +5

Estrogen distinctly regulates transcription and translation of lncRNAs and pseudogenes in breast cancer cells

Siew-Woh Choo, Yu Zhong, Edward Sendler, +6

Genomics

Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer

Jun Liang, Jun Li, Robert A. Blake, +28

Bioorganic & Medicinal Chemistry Letters

Potent DegraderBreast OncologyEndocrine-related CancerMedicineHormonal Receptor +7