Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling

Yoku Hayakawa, Kosuke Sakitani, Mitsuru Konishi, +24

Cancer Cell

Signal TransductionAberrant CholinergicGastrointestinal OncologyTumor InnervationGastroenterology +5

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

Bernhard W. Renz, Ryota Takahashi, Takayuki Tanaka, +27

Cancer Cell

Tumor BiologyPancreatic CancerMedicinePathologyPharmacology +1

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

Bernhard W. Renz, Takayuki Tanaka, Masaki Sunagawa, +22

Cancer Discovery

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

C. Benedikt Westphalen, Yoshihiro Takemoto, Takayuki Tanaka, +26

Cell stem cell

Promote Injury-induced RegenerationLineage PlasticityDevelopmental BiologyPancreatic CancerMedicine +5

Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression

Ryota Takahashi, Marina Macchini, Masaki Sunagawa, +13

Gut

Nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in metastatic pancreatic adenocarcinoma (PACT-19): a randomised phase 2 trial

Michele Reni, Silvia Zanon, Umberto Peretti, +12

˜The œLancet. Gastroenterology & hepatology

Pancreatic CancerGastrointestinal OncologyMetastatic Pancreatic AdenocarcinomaMedicinePharmacology +5

EUS-guided gastroenterostomy for management of malignant gastric outlet obstruction: a prospective cohort study with matched comparison with enteral stenting

Giuseppe Vanella, Giuseppe Dell’Anna, Gabriele Capurso, +12

Gastrointestinal Endoscopy

Matched ComparisonGastroenterologyEus-guided GastroenterostomySurgeryUpper Gastrointestinal Surgery +3

A randomised phase 2 trial of nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in locally advanced or borderline resectable pancreatic adenocarcinoma

Michele Reni, Silvia Zanon, Gianpaolo Balzano, +14

European Journal of Cancer

Surgical OncologyOncologyPancreatic CancerGastrointestinal OncologyMedicine +7

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

Zhengyu Jiang, Feijing Wu, Pasquale Laise, +25

Cell stem cell

Lineage PlasticityDevelopmental BiologySignaling PathwayPancreatic CancerCell Regulation +6

Characterization of pancreatic ductal adenocarcinoma using whole transcriptome sequencing and copy number analysis by single-nucleotide polymorphism array

Mariacristina Di Marco, Annalisa Astolfi, Elisa Grassi, +16

Molecular Medicine Reports

Parallel SequencingGeneticsPathologyTranscriptomics TechnologyGenomics +19