Extra-embryonic function of Rb is essential for embryonic development and viability

Lizhao Wu, Alain de Bruin, Harold I. Saavedra, +13

Nature

Developmental BiologyCell SpecializationExtra-embryonic FunctionDevelopmental GeneticsGenetics +6

Mouse development with a single E2F activator

Shih‐Yin Tsai, René Opavský, Nidhi Sharma, +13

Nature

Knockout MouseDevelopmental BiologyMedicineIn Vivo SystemOptogenetics +2

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Staci L. Haney, G. Michael Upchurch, Jana Opavska, +6

PLoS Genetics

Histone ModificationsLymphocyte DevelopmentEpigenetic ChangeDna MethylationImmunology +22

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

Ryan A. Hlady, Slavomíra Nováková, Jana Opavska, +18

Journal of Clinical Investigation

Histone ModificationsEpigenetic ChangeImmunologyCytosine MethylationCancer Biology +15

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

René Opavský, Shih‐Yin Tsai, Martin Guimond, +12

Proceedings of the National Academy of Sciences

Essential Role for Dnmt1 in the Prevention and Maintenance of MYC-Induced T-Cell Lymphomas

Staci L. Peters, Ryan A. Hlady, Jana Opavska, +8

Molecular and Cellular Biology

Epigenetic ChangeGeneticsDna MethylationImmunologyDna Cytosine Methylation +17

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Paweł Nowialis, Katarína Lopušná, Jana Opavska, +10

Nature Communications

Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a

Staci L. Haney, G. Michael Upchurch, Jana Opavska, +12

Cell Reports

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Staci L. Haney, Ryan A. Hlady, Jana Opavska, +7

Oncogene

Dnmt3b ContributesLineage PlasticitySystems BiologyLymphocyte DevelopmentEpigenetic Change +7

Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice

Staci L. Haney, G. Michael Upchurch, Jana Opavska, +7

Scientific Reports