Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)

Takao Ashikaga, Yukiko Yoshida, Morihiko Hirota, +7

Toxicology in Vitro

Skin DevelopmentAllergySkin AllergyHuman Cell LinesWound Healing +5

Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT

H. Sakaguchi, Takao Ashikaga, Masaaki Miyazawa, +7

Toxicology in Vitro

Inter-laboratory StudyAllergyCutaneous BiologyImmunologySkin Allergy +7

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

Osamu Takenouchi, Shiho Fukui, Kenji Okamoto, +14

Journal of Applied Toxicology

Chemical Data SetSkin AllergyDermatologyDirect Peptide ReactivityBioanalysis +20

Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

Yuko Nukada, Takao Ashikaga, Masaaki Miyazawa, +4

Toxicology in Vitro

Skin Sensitization PotencyMedicineSkin AllergyToxicologyDermatology +2

QUANTITATIVE MEASUREMENT OF SPLICED XBP1 mRNA AS AN INDICATOR OF ENDOPLASMIC RETICULUM STRESS

Morihiko Hirota, Masato Kitagaki, Hiroshi Itagaki, +1

The Journal of Toxicological Sciences

Molecular BiologyEr StressUnfolded ProteinSplicing VariantProtein Expression +14

Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT)

Yuko Nukada, Takao Ashikaga, Hitoshi Sakaguchi, +7

Contact Dermatitis

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients

N. Gilmour, Petra Kern, Nathalie Alépée, +15

Regulatory Toxicology and Pharmacology

Human Safety AssessmentAllergyAtopic DermatitisEnvironmental HealthRisk Management +10

Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test

Mie Suzuki, Morihiko Hirota, Shigenobu Hagino, +2

Toxicology in Vitro

Immunocytochemical TechniqueAllergyVitro Sensitization TestBioanalysisImmunology +10

Evaluation of combinations of <i>in vitro</i> sensitization test descriptors for the artificial neural network‐based risk assessment model of skin sensitization

Morihiko Hirota, Shiho Fukui, Kenji Okamoto, +14

Journal of Applied Toxicology

Skin AllergyDermatologyLlna ThresholdTranslational MedicineLlna Thresholds +14

Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

Kyoko Tsujita‐Inoue, Morihiko Hirota, Takao Ashikaga, +3

Toxicology in Vitro

Vitro AssaysAllergyAtopic DermatitisSkin AllergyBiostatistics +4