Assessing skin sensitization hazard in mice and men using non-animal test methods

Daniel Urbisch, Annette Mehling, Katharina Guth, +12

Regulatory Toxicology and Pharmacology

ImmunologySkin AllergySingle Test MethodsDermatologyNon-animal Test Methods +15

Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)

Takao Ashikaga, Yukiko Yoshida, Morihiko Hirota, +7

Toxicology in Vitro

Skin DevelopmentAllergySkin AllergyHuman Cell LinesWound Healing +5

Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT

H. Sakaguchi, Takao Ashikaga, Masaaki Miyazawa, +7

Toxicology in Vitro

Inter-laboratory StudyAllergyCutaneous BiologyImmunologySkin Allergy +7

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

Joanna Jaworska, Andreas Natsch, Cindy A. Ryan, +3

Archives of Toxicology

Bayesian StatisticsDecision Support SystemSoftware TestingDiagnosisClinical Dermatology +9

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

Kerstin Reisinger, Sebastian Hoffmann, Nathalie Alépée, +25

Toxicology in Vitro

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

Osamu Takenouchi, Shiho Fukui, Kenji Okamoto, +14

Journal of Applied Toxicology

Chemical Data SetSkin AllergyDermatologyDirect Peptide ReactivityBioanalysis +20

A Comparative Evaluation of <i>In Vitro</i> Skin Sensitisation Tests: The Human Cell-line Activation Test (h-CLAT) <i>versus</i> the Local Lymph Node Assay (LLNA)

Takao Ashikaga, Hitoshi Sakaguchi, Sakiko Sono, +7

Alternatives to Laboratory Animals

ImmunotoxicologyImmune RegulationImmunologySkin AllergyDermatology +15

Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

Yuko Nukada, Takao Ashikaga, Masaaki Miyazawa, +4

Toxicology in Vitro

Skin Sensitization PotencyMedicineSkin AllergyToxicologyDermatology +2

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)

Hitoshi Sakaguchi, Takao Ashikaga, Masaaki Miyazawa, +7

Cell Biology and Toxicology

AllergyCd86/cd54 ExpressionCutaneous BiologyImmunologyThp-1 Cell Viability +7

Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers

Takao Ashikaga, Miguel de la Hoya, Hiroshi Itagaki, +2

Toxicology in Vitro

Autoimmune DiseaseAllergyImmunologyImmune RegulationContact Sensitizers +9