Optimized base editors enable efficient editing in cells, organoids and mice

María Paz Zafra, Emma M. Schatoff, Alyna Katti, +15

Nature Biotechnology

EngineeringGenome SurgeryMedicineComputational BiologySynthetic Biology +8

An <i>In Vivo Kras</i> Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants

María Paz Zafra, Marie J. Parsons, Jangkyung Kim, +9

Cancer Discovery

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Francisco J. Sánchez‐Rivera, Bianca J. Diaz, Edward R. Kastenhuber, +18

Nature Biotechnology

High-throughput EngineeringFunctional GenomicsEngineeringGenome SurgeryBiomolecular Tool +11

Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition

Emma M. Schatoff, Sukanya Goswami, María Paz Zafra, +6

Cancer Discovery

GO: a functional reporter system to identify and enrich base editing activity

Alyna Katti, Miguel Foronda, J. Lynn Zimmerman, +4

Nucleic Acids Research

Lineage Reversion Drives WNT Independence in Intestinal Cancer

Teng Han, Sukanya Goswami, Yang Hu, +11

Cancer Discovery

Myocardial infarction augments sleep to limit cardiac inflammation and damage

Pacific Huynh, Jan D. Hoffmann, Teresa Gerhardt, +34

Nature

InflammationSleepHeart FailureMyocardial Infarction AugmentsSleep Disorder +7

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis

Máté G. Kiss, John E. Mindur, Abi G. Yates, +25

Immunity

Autoimmune DiseaseMedicineImmunologyImmune RegulationAutoimmunity +5

Generation of precision preclinical cancer models using regulated in vivo base editing

Alyna Katti, Adrián Vega‐Pérez, Miguel Foronda, +16

Nature Biotechnology

Tumor HeterogeneityPreclinical ModelsVivo Base EditingMedicineCancer Genomics +10

Tankyrase inhibition sensitizes cells to CDK4 blockade

Miguel Foronda, Yusuke Tarumoto, Emma M. Schatoff, +7

PLoS ONE

Tumor BiologyInhibitory ActivityTankyrase InhibitionSignal TransductionTnks Inhibitors +12