Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

Benjamin Le Calvé, Michał Rynkowski, Marie Le Mercier, +9

Neoplasia

Vitro TreatmentMetabolic RemodelingHigh-grade GliomasCancer BiologyGlioma +17

Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways

Caroline Lonez, Michel Bessodes, Daniel Scherman, +3

Nanomedicine Nanotechnology Biology and Medicine

InflammationToll-like ReceptorsNanomedicineAnti-inflammatoryImmunology +7

DiC14‐amidine cationic liposomes stimulate myeloid dendritic cells through Toll‐like receptor 4

Tetsuya Tanaka, Amandine Legat, Emmanuelle Adam, +10

European Journal of Immunology

CYAD-01, an autologous NKG2D-based CAR T-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK): haematological cohorts of the dose escalation segment of a phase 1 trial

David A. Sallman, Tessa Kerre, Violaine Havelange, +16

The Lancet Haematology

Hematological MalignancyCell TherapyDose Escalation SegmentCellular TherapiesMedicine +9

NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient

David A. Sallman, Jason Brayer, Elizabeth M. Sagatys, +7

Haematologica

Hematological MalignancyCell TherapyMalignant Blood DisorderHematologyImmunology +3

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4

Malvina Pizzuto, Caroline Lonez, Alberto Baroja‐Mazo, +7

Cellular and Molecular Life Sciences

Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure

Adelin Gustot, Vincent Raussens, Morgane Dehousse, +4

Cellular and Molecular Life Sciences

Cross-β Sheet StructureMolecular ImmunologyProtein FunctionVirulence FactorPathogenesis +6

Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

Caroline Lonez, Bikash Verma, Alain Hendlisz, +13

BMJ Open

Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface

Caroline Lonez, Katherine L. Irvine, Malvina Pizzuto, +5

Cellular and Molecular Life Sciences

Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages

María Georgina Herrera, Malvina Pizzuto, Caroline Lonez, +5

Nanomedicine Nanotechnology Biology and Medicine

InflammationToll-like ReceptorsSignal TransductionG Protein-coupled ReceptorInnate Immune System +7