Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies

Maria Antonia Frassanito, Luigia Rao, Michele Moschetta, +15

Leukemia

Hematological MalignancyMultiple Myeloma ProgressionVivo StudiesBone Marrow FailureBone Marrow Fibroblasts +8

Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients

Maria Antonia Frassanito, Kim De Veirman, Vanessa Desantis, +17

Leukemia

Hematological MalignancyCell AutophagyImmunologyHematologyAutophagy +6

A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target

Arianna Ferrucci, Michele Moschetta, Maria Antonia Frassanito, +15

Clinical Cancer Research

Multiple Myeloma Macrophages: Pivotal Players in the Tumor Microenvironment

Simona Berardi, Roberto Ria, Antonia Reale, +4

Journal of Oncology

InflammationCytokineAngiogenesisMm Bone MarrowMultiple Myeloma Macrophages +11

HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

Roberto Ria, Ivana Catacchio, Simona Berardi, +17

Clinical Cancer Research

Evidence for Bone Marrow Adult Stem Cell Plasticity: Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation

Ivana Catacchio, Simona Berardi, Antonia Reale, +4

Stem Cells International

Tissue Lineage BoundariesAdult Stem CellEmbryologyRegenerative MedicineStem Cell Mobilization +15

Hemilipin, a novel Hemiscorpius lepturus venom heterodimeric phospholipase A2, which inhibits angiogenesis in vitro and in vivo

I. Jridi, Ivana Catacchio, Hafed Majdoub, +6

Toxicon

ThrombosisAngiogenesisMedicineHematologyVenomics +4

Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients

Ivana Catacchio, Nicola Silvestris, Emanuela Scarpi, +3

Translational Oncology

Four proteins governing overangiogenic endothelial cell phenotype in patients with multiple myeloma are plausible therapeutic targets

Simona Berardi, Antonella Caivano, Roberto Ria, +17

Oncogene

Endothelial Cell PathobiologyHematological MalignancyAngiogenesisMalignant Blood DisorderImmunology +7

The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein

I. Jridi, Ivana Catacchio, Hafed Majdoub, +7

Toxicon

Signal TransductionWhole ProteinBiochemistryToxinologyVenomics +4