A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

Qiurong Ding, Youn‐Kyoung Lee, Esperance Schaefer, +25

Cell stem cell

Induced Pluripotent Stem CellFunctional GenomicsGenome SurgeryMedicineGenetics +10

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9

Pankaj Kumar Mandal, Leonardo M. R. Ferreira, Ryan L. Collins, +13

Cell stem cell

Off-target EffectMedicineGeneticsHuman Hematopoietic StemGenetic Engineering +9

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Curtis R. Warren, John O’Sullivan, Max Friesen, +24

Cell stem cell

Genome-wide Association StudyInduced Pluripotent Stem CellFunctional GenomicsMetabolic DiseaseInherited Metabolic Disease +8

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

Zhifen Chen, Haojie Yu, Xu Shi, +8

Circulation Research

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells

Derek Peters, Christopher A. Henderson, Curtis R. Warren, +4

Development

Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes

Max Friesen, Curtis R. Warren, Haojie Yu, +8

Stem Cell Reports

Metabolic RemodelingAdipokinesHuman AdipocytesOxidative StressObesity +17

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

Alessandra Dall’Agnese, Jesse M. Platt, Ming Zheng, +17

Nature Communications

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons

Yi Liu, Anthony Flamier, George W. Bell, +12

Neuron

Human NeuronsTranscriptional RegulationSignal TransductionMolecular NeuroscienceRna Polymerase Ii +10

The platelet as a mediator of tissue damage in immune complex glomerulonephritis.

Clark Wf, Max Friesen, Linton Al, +1

PubMed

InflammationGlomerular DiseaseGlomerulonephritisImmune Complex GlomerulonephritisAutoimmune Disease +13

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

Takafumi Toyohara, Filip Roudnicky, Mary H.C. Florido, +12

Cell stem cell

Vascular DiseaseCardiovascular DiseasePathologyVascular BiologyArterial Disease Treatment +5