Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

Kensuke Tateishi, Hiroaki Wakimoto, A. John Iafrate, +26

Cancer Cell

Genome InstabilityCancer GenomicsExtreme VulnerabilityCancer GeneticsMedicine +2

Metabolic Signatures of Exercise in Human Plasma

Gregory D. Lewis, Laurie Farrell, Malissa J. Wood, +20

Science Translational Medicine

A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort

Eugene P. Rhee, Jennifer E. Ho, Ming‐Huei Chen, +18

Cell Metabolism

Genome-wide Association StudyGenetic EpidemiologyCommunity-based CohortMetabolomic ProfilingHuman Metabolome +9

Quantification of Cardiovascular Biomarkers in Patient Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution

Hasmik Keshishian, Terri A. Addona, Michael Burgess, +6

Molecular & Cellular Proteomics

A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease

Terri A. Addona, Xu Shi, Hasmik Keshishian, +11

Nature Biotechnology

Biomarker (Medicine)Prognostic BiomarkersEngineeringCardiovascular DiseaseCandidate Markers +12

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease

Debby Ngo, Sumita Sinha, Dongxiao Shen, +14

Circulation

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Curtis R. Warren, John O’Sullivan, Max Friesen, +24

Cell stem cell

Genome-wide Association StudyInduced Pluripotent Stem CellFunctional GenomicsMetabolic DiseaseInherited Metabolic Disease +8

Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension

Gregory D. Lewis, Debby Ngo, Anna R. Hemnes, +11

Journal of the American College of Cardiology

Pulmonary Arterial HypertensionPulmonary CirculationCardiovascular DiseasePhysiologyPulmonary Hypertension +7

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

John A. Bennett, Michael A. Mastrangelo, Sara Ture, +16

Nature Communications

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes

Zhifen Chen, Haojie Yu, Xu Shi, +8

Circulation Research