John Attanasio

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Omar Khan, Josephine R. Giles, Sierra McDonald et al. · Nature · 2019 · 1.5K citations

Transcriptional Regulation, T-regulatory Cell, Gene Expression +3

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bertram Bengsch, Andrew L. Johnson, Makoto Kurachi et al. · Immunity · 2016 · 775 citations · Full text

Metabolic Alterations, Bioenergetic Insufficiencies Due, Signal Transduction +15

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

Laura M. McLane, Shin Foong Ngiow, Zeyu Chen et al. · Cell Reports · 2021 · 118 citations · Full text

Inhibitory signaling sustains a distinct early memory CD8 ⁺ T cell precursor that is resistant to DNA damage

Jonathan B. Johnnidis, Yuki Muroyama, Shin Foong Ngiow et al. · Science Immunology · 2021 · 79 citations · Full text

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function

Makoto Kurachi, Junko Kurachi, Zeyu Chen et al. · Nature Protocols · 2017 · 75 citations · Full text

Mouse T Cells, Retroviral Transduction, Adaptive Immune System +11