Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice

Soichiro Tajima, Yasumasa Ikeda, Kaori Sawada, +10

American Journal of Physiology-Endocrinology and Metabolism

Metabolic DisorderIron MetabolismLipid PeroxidationRedox BiologyOxidative Stress +15

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

Yasumasa Ikeda, Iori Ozono, Soichiro Tajima, +8

PLoS ONE

Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice

Yasumasa Ikeda, Hirofumi Hamano, Yuya Horinouchi, +5

Journal of Trace Elements in Medicine and Biology

MedicineCisplatin-induced Acute NephrotoxicityPharmacologyRedox BiologyNephrology +3

The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease

Hirofumi Hamano, Yasumasa Ikeda, Hiroaki Watanabe, +9

Nephrology Dialysis Transplantation

Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice

Yasumasa Ikeda, Hiroaki Watanabe, Tetsuya Shiuchi, +12

Diabetologia

ObesityMetabolic SyndromeInflammationNutritionMetabolic Disorder +9

Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity

Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, +16

Kidney International

UrologyMedicineMetronomic TherapyToxicologyPharmacotherapy +4

Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3–E3 ubiquitin ligase-dependent pathway

Yasumasa Ikeda, Mizuki Imao, Akiho Satoh, +9

Journal of Trace Elements in Medicine and Biology

Muscle FunctionMolecular PhysiologyMuscle InjurySkeletal MuscleIron Metabolism +4

Iron accumulation causes impaired myogenesis correlated with MAPK signaling pathway inhibition by oxidative stress

Yasumasa Ikeda, Akiho Satoh, Yuya Horinouchi, +14

The FASEB Journal

Characteristics of and Risk Factors for Interstitial Lung Disease Induced by Chemotherapy for Lung Cancer

Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, +10

Annals of Pharmacotherapy

Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway

Hirofumi Hamano, Takahiro Niimura, Yuya Horinouchi, +13

Toxicology Letters

Direct RegulationBiochemistryMedicineMetalloproteinProton Pump Inhibitors +7