Resolving medulloblastoma cellular architecture by single-cell genomics

Volker Hovestadt, Kyle Smith, Laure Bihannic, +48

Nature

Tumor HeterogeneityMedicineSingle Cell SequencingSingle-cell BiologySingle-cell Genomics +3

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo, Bernhard Englinger, Li Jiang, +38

Cancer Cell

Cell LineageDevelopmental BiologySingle Cell SequencingMedicineSingle-cell Genomics +8

POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

Anna Schrempf, Sara Bernardo, Emili A. Arasa Verge, +11

Cell Reports

GeneticsSsdna GapsMolecular BiologyMolecular GeneticsCell Cycle +18

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

Johannes Gojo, Daniela Lötsch, Sabine Spiegl‐Kreinecker, +22

Neuro-Oncology

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, +17

Acta Neuropathologica Communications

The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation

Dina Baier, Beatrix Schoenhacker‐Alte, Mate Rusz, +12

Pharmaceutics

Chemoprevention StrategyMetabolic RemodelingCancer BiologyBold-100 ResistanceTumor Biology +18

Targeting fibroblast growth factor receptors to combat aggressive ependymoma

Daniela Lötsch, Dominik Kirchhofer, Bernhard Englinger, +34

Acta Neuropathologica

Neuro-oncologyTumor InnervationGliomaFgfr InhibitionFgfr Inhibitors +10

Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

Lisa Mayr, Armin Sebastian Guntner, Sibylle Madlener, +26

Journal of Personalized Medicine

Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis

Alicia Baumgartner, Natalia Stepien, Lisa Mayr, +22

Journal of Personalized Medicine

Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness

Lisa Gabler, Carola Jaunecker, Sonja Katz, +27

Acta Neuropathologica Communications

Promotes Glioblastoma ProgressionHigh-grade GliomasGliomaTumor BiologyIntegrin-mediated Cell Invasiveness +19