Ashleigh J. Burke

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese et al. · Nature · 2019 · 168 citations

Life Sciences, Biochemistry, Biotechnology +12

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Rebecca Crawshaw, Amy E. Crossley, Linus O. Johannissen et al. · Nature Chemistry · 2021 · 107 citations · Full text

Engineering, Biotechnology, Chemistry +12

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Ashleigh J. Burke, William R. Birmingham, Ying Zhuo et al. · Journal of the American Chemical Society · 2022 · 51 citations · Full text

Engineering, Biotechnology, Molecular Biology +17

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir

Hans D. Preschel, Ruben T. Otte, Ying Zhuo et al. · The Journal of Organic Chemistry · 2023 · 19 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +13

Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines

Ashleigh J. Burke, Thomas M. Lister, James R. Marshall et al. · ChemCatChem · 2023 · 14 citations · Full text

Engineering, Biotechnology, Chemistry +15