Ashleigh J. Burke

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese et al. · Nature · 2019 · 162 citations

Biochemistry, Natural Sciences, Biocatalysis +8

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Rebecca Crawshaw, Amy E. Crossley, Linus O. Johannissen et al. · Nature Chemistry · 2021 · 103 citations · Full text

Engineering, Biochemistry, Natural Sciences +8

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Ashleigh J. Burke, William R. Birmingham, Ying Zhuo et al. · Journal of the American Chemical Society · 2022 · 48 citations · Full text

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir

Hans D. Preschel, Ruben T. Otte, Ying Zhuo et al. · The Journal of Organic Chemistry · 2023 · 16 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +13

Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines

Ashleigh J. Burke, Thomas M. Lister, James R. Marshall et al. · ChemCatChem · 2023 · 12 citations · Full text