Aimee L. Crombie

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Xiaotao Chen, Philip Pitis, Guodong Liu et al. · Journal of Medicinal Chemistry · 2013 · 193 citations · Full text

Ring Expansion-Annulation Strategy for the Synthesis of Substituted Azulenes and Oligoazulenes. 2. Synthesis of Azulenyl Halides, Sulfonates, and Azulenylmetal Compounds and Their Application in Transition-Metal-Mediated Coupling Reactions

Aimee L. Crombie, John L. Kane, Kevin M. Shea et al. · The Journal of Organic Chemistry · 2004 · 101 citations

Medicinal Chemistry, Enantioselective Synthesis, Ring Expansion-annulation Strategy +11

Synthesis of Polycyclic Benzofused Nitrogen Heterocycles via a Tandem Ynamide Benzannulation/Ring-Closing Metathesis Strategy. Application in a Formal Total Synthesis of (+)-FR900482

Xiao Yin Mak, Aimee L. Crombie, Rick Danheiser · The Journal of Organic Chemistry · 2011 · 91 citations · Full text

Medicinal Chemistry, Natural Product Synthesis, Heterocyclic +14

A Ring Expansion−Annulation Strategy for the Synthesis of Substituted Azulenes. Preparation and Suzuki Coupling Reactions of 1-Azulenyl Triflates

John L. Kane, Kevin M. Shea, Aimee L. Crombie et al. · Organic Letters · 2001 · 79 citations

Delta opioid receptor agonists are effective for multiple types of headache disorders

Laura S. Moye, Alycia F Tipton, Isaac Dripps et al. · Neuropharmacology · 2018 · 72 citations · Full text

Cluster Headache, Neurophysiology, Pain Medicine +11