Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial

Nirav N. Shah, Bryon D. Johnson, Dina Schneider, +13

Nature Medicine

Cancer ImmunosurveillanceDose EscalationMedicineImmunologyExpansion Trial +5

A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines

Dina Schneider, Ying Xiong, Darong Wu, +5

Journal for ImmunoTherapy of Cancer

Adaptive Immune SystemImmunologyImmunoeditingImmunodominanceAntigen Processing +18

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

Qiong Wang, Deepti R. Nagarkar, Emily Bowman, +9

The Journal of Immunology

Viral ReplicationInflammatory Lung DiseaseRespiratory DiseasesQuantitative PcrMedicine +12

Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

Dina Schneider, Shyamala Ganesan, Adam T. Comstock, +7

American Journal of Respiratory and Critical Care Medicine

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Haneen Shalabi, Haiying Qin, Angela Su, +32

Blood

Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice

Dan Li, Nan Li, Yifan Zhang, +24

Gastroenterology

Cancer ImmunosurveillanceLiver PhysiologyImmunologyLiver CancerImmunotherapy +3

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

Kim Anthony-Gonda, Ariola Bardhi, Alex Ray, +13

Science Translational Medicine

Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models

Dina Schneider, Ying Xiong, Darong Wu, +10

Science Translational Medicine

MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

Qiong Wang, David J. Miller, Emily Bowman, +8

PLoS Pathogens

AsthmaInflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunology +15

Closed-system manufacturing of CD19 and dual-targeted CD20/19 chimeric antigen receptor T cells using the CliniMACS Prodigy device at an academic medical center

Fenlu Zhu, Nirav N. Shah, Huiqing Xu, +5

Cytotherapy

Closed-system ManufacturingMedicineAcademic Medical CenterImmunologyAntigen Processing +8