Chromosome errors in human eggs shape natural fertility over reproductive life span

Jennifer R. Gruhn, Agata P. Zielinska, Vallari Shukla, +27

Science

Chromosome ErrorsFertilityGeneticsReproductive HealthGynecology +16

Germline rates of de novo meiotic deletions and duplications causing several genomic disorders

Daniel J. Turner, Marcos Miretti, Diana Rajan, +5

Nature Genetics

Developmental BiologyGerm CellGenetic DisorderGeneticsMeiosis +6

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

Zuzana Holubcová, Martyn Blayney, Kay Elder, +1

Science

OocyteFertilityGeneticsMolecular BiologyHuman Eggs +19

Rheotaxis facilitates upstream navigation of mammalian sperm cells

Vasily Kantsler, Jörn Dunkel, Martyn Blayney, +1

eLife

EngineeringFertilityFluid MechanicsMammalian SpermSemen Analysis +17

Stage-Specific Expression of Cytokine and Receptor Messenger Ribonucleic Acids in Human Preimplantation Embryos1

Andrew Sharkey, Kim Dellow, Martyn Blayney, +3

Biology of Reproduction

A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years' experience

Amir Lass, Fidelis Akagbosu, Naim Abusheikha, +4

Human Reproduction

FertilitySemen CryopreservationReproductive HealthGynecologySemen Analysis +18

Parental genome unification is highly error-prone in mammalian embryos

Tommaso Cavazza, Yuko Takeda, Antonio Z. Politi, +12

Cell

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

Shiya Cheng, Gerrit Altmeppen, Chun So, +11

Science

OocyteFull-grown OocytesDevelopmental BiologyMitochondrial BiogenesisMitochondrial Function +12

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

Agata P. Zielinska, Zuzana Holubcová, Martyn Blayney, +2

eLife

Mechanism of spindle pole organization and instability in human oocytes

Chun So, Katerina Menelaou, Julia Uraji, +13

Science