Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

Bruno Gomes, Grégory Driessens, Derek W. Bartlett, +25

Molecular Cancer Therapeutics

IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

Reece Marillier, Chesney Michels, Elizabeth M. Smith, +5

BMC Immunology

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Julie Preillon, Julia Cuende, Virginie Rabolli, +24

Molecular Cancer Therapeutics

IL-4Rα-Independent Expression of Mannose Receptor and Ym1 by Macrophages Depends on their IL-10 Responsiveness

Benjamin G Dewals, Reece Marillier, J. Claire Hoving, +3

PLoS neglected tropical diseases

Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

Ludovic Belle, Kimberle A. Agle, Vivian Zhou, +12

Blood

TH1-Dominant Granulomatous Pathology Does Not Inhibit Fibrosis or Cause Lethality during Murine Schistosomiasis

Mosiuoa Leeto, De’Broski R. Herbert, Reece Marillier, +3

American Journal Of Pathology

Murine SchistosomiasisFibrosisAutoimmune DiseasePathogenesisImmunology +10

Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in<i>L. major</i>infection

Catherine Uyttenhove, Reece Marillier, Fabienne Tacchini‐Cottier, +9

Journal of Leukocyte Biology

IL-4Rα Responsiveness of Non-CD4 T Cells Contributes to Resistance in Schistosoma mansoni Infection in Pan-T Cell-Specific IL-4Rα-Deficient Mice

Benjamin G Dewals, J. Claire Hoving, Mosiuoa Leeto, +5

American Journal Of Pathology

Schistosoma Mansoni InfectionAutoimmune DiseaseMedicinePathogenesisImmunology +9

Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors

Joseph R. Tumang, Bruno Gomes, Martin Wythes, +36

Cancer Research

Immune RegulationImmunologyImmunologic MechanismBiological TherapyImmunotherapeutics +18

IL-4Rα-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis

Reece Marillier, Tiroyaone M. Brombacher, Benjamin G Dewals, +6

American Journal of Physiology-Gastrointestinal and Liver Physiology