GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Robbie G. Majzner, Sneha Ramakrishna, Kristen W. Yeom, +44

Nature

Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework

Sean V. Tavtigian, Marc S. Greenblatt, Steven M. Harrison, +4

Genetics in Medicine

Data ClassificationClassification MethodEngineeringBayesian Hierarchical ModelingData Science +10

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber, Kevin R. Parker, Elena Sotillo, +23

Science

Caenorhabditis elegans mutant allele identification by whole-genome sequencing

Sumeet Sarin, Snehit Prabhu, M O’Meara, +2

Nature Methods

Allele IdentificationNext-generation SequencingGeneticsGenome AnalysisMolecular Genetics +3

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

Zinaida Good, Jay Y. Spiegel, Bita Sahaf, +27

Nature Medicine

Cell TherapyCellular TherapiesT-regulatory CellImmunologySelf-tolerance +8

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

Michelle Monje, Jasia Mahdi, Robbie G. Majzner, +51

Nature

Optimal fludarabine lymphodepletion is associated with improved outcomes after CAR T-cell therapy

Vanessa A. Fabrizio, Jaap Jan Boelens, Audrey Mauguen, +29

Blood Advances

Cell TherapyOptimal Fludarabine ExposureImmunologyImmunotherapyHematological Malignancy +17

Overlapping pools for high-throughput targeted resequencing

Snehit Prabhu, Itsik Pe’er

Genome Research

Cluster ComputingGenetic TestingEngineeringGeneticsComputer Architecture +23

Tisagenlecleucel outcomes in relapsed/refractory extramedullary ALL: a Pediatric Real World CAR Consortium Report

Vanessa A. Fabrizio, Christine L. Phillips, Adam Lane, +28

Blood Advances

Isolated Cns RelapseImmunologySurgeryTisagenlecleucel OutcomesImmunotherapy +16

Outcomes After Nonresponse and Relapse Post-Tisagenlecleucel in Children, Adolescents, and Young Adults With B-Cell Acute Lymphoblastic Leukemia

Liora M. Schultz, Anne Eaton, Christina Baggott, +28

Journal of Clinical Oncology