Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

Sandra Gemma, Gagan Kukreja, Caterina Fattorusso, +10

Bioorganic & Medicinal Chemistry Letters

Antiparasitic AgentMedicineMalariaAntimicrobial ChemotherapyPotent Antimalarial Agents +3

Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT₃ Receptor Agonists:  Synthesis, Further Structure−Activity Relationships, and Biological Studies

Giuseppe Campiani, Elena Morelli, Sandra Gemma, +12

Journal of Medicinal Chemistry

Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

Margherita Brindisi, A. Prasanth Saraswati, Simone Brogi, +3

Journal of Medicinal Chemistry

Synthesis and Pharmacological Evaluation of Potent and Highly Selective D₃ Receptor Ligands:  Inhibition of Cocaine-Seeking Behavior and the Role of Dopamine D₃/D₂ Receptors

Giuseppe Campiani, Stefania Butini, Francesco Trotta, +12

Journal of Medicinal Chemistry

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

Margherita Brindisi, Samuele Maramai, Sandra Gemma, +24

Journal of Medicinal Chemistry

NeuropeptidesPain MedicineCompound 4AMolecular PainPharmacotherapy +18

Discovery of a New Class of Potential Multifunctional Atypical Antipsychotic Agents Targeting Dopamine D₃and Serotonin 5-HT_1Aand 5-HT_2AReceptors: Design, Synthesis, and Effects on Behavior

Stefania Butini, Sandra Gemma, Giuseppe Campiani, +19

Journal of Medicinal Chemistry

Design, Synthesis, and Structure–Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents

Caterina Fattorusso, Giuseppe Campiani, Gagan Kukreja, +17

Journal of Medicinal Chemistry

Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663

Giovanni Maga, Sandra Gemma, Caterina Fattorusso, +11

Biochemistry

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

Margherita Brindisi, Simone Brogi, Nicola Relitti, +10

Scientific Reports

Computational Tool for Fast in silico Evaluation of hERG K+ Channel Affinity

Giulia Chemi, Sandra Gemma, Giuseppe Campiani, +3

Frontiers in Chemistry