PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

Nirav Dhanesha, Rakesh B. Patel, Prakash Doddapattar, +8

Blood

Neutrophil ActivationPkm2 Nuclear TranslocationImmunologyCell DeathCerebrovascular Disease +21

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Prakash Doddapattar, Rishabh Dev, Madankumar Ghatge, +5

Circulation Research

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Manasa K. Nayak, Madankumar Ghatge, Gagan D. Flora, +6

Blood

Network Analysis of Inflammatory Genes and Their Transcriptional Regulators in Coronary Artery Disease

Jiny Nair, Madankumar Ghatge, Vijay V. Kakkar, +1

PLoS ONE

ImmunologyNetwork AnalysisGene Regulatory NetworkGene Expression ProfilingCoronary Artery Disease +18

Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation

Nirav Dhanesha, Manish Jain, Amit Kumar Tripathi, +8

Circulation Research

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, +3

Blood Advances

Metabolic RemodelingAerobic Glycolysis RelativeOxidative StressThrombosisMetabolic Syndrome +21

Targeting Neutrophil α9 Improves Functional Outcomes After Stroke in Mice With Obesity-Induced Hyperglycemia

Rakesh B. Patel, Nirav Dhanesha, Brijesh Sutariya, +6

Stroke

Association of γ-glutamyl transferase with premature coronary artery disease

Madankumar Ghatge, Ankit Sharma, Rajani Kanth Vangala

Biomedical Reports

Cardiometabolic RiskHyperlipidemiaPreventive CardiologyReference TertileCoronary Artery Disease +17

Integrative Bioinformatics Analysis of Genomic and Proteomic Approaches to Understand the Transcriptional Regulatory Program in Coronary Artery Disease Pathways

Rajani Kanth Vangala, Vandana Ravindran, Madankumar Ghatge, +5

PLoS ONE

EngineeringGeneticsMultiomicsTranscriptomics TechnologyGene Expression Profiling +22

Understanding the progression of atherosclerosis through gene profiling and co-expression network analysis in Apob tm2Sgy Ldlr tm1Her double knockout mice

Vrushali Deshpande, Ankit Sharma, Rupak Mukhopadhyay, +5

Genomics

InflammationMetabolic SyndromeVascular DiseaseGene ProfilingMedicine +8