Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, +20

Nature Metabolism

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, +12

eLife

Glutathione DisulfideImmunologyImmunologic MechanismRedox HomeostasisRedox Biology +20

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

Yuetong Wang, Fei Wang, Lihua Wang, +14

Cell Reports

Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

JN Rashida Gnanaprakasam, Bhavana Kushwaha, Lingling Liu, +14

Nature Metabolism

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Ruohan Wu, Xuyong Chen, Siwen Kang, +7

Science Advances

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

Xuyong Chen, Benjamin D. Sunkel, Meng Wang, +14

Science Immunology

ImmunologyMetabolic RemodelingOxidative StressSdh/complex Ii DeficiencyInflammation +25

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent

Tingting Wang, Lingling Liu, Xuyong Chen, +6

Cell Death and Disease

Intestinal proinflammatory macrophages induce a phenotypic switch in interstitial cells of Cajal

Xuyong Chen, Xinyao Meng, Hongyi Zhang, +14

Journal of Clinical Investigation

Diagnostic value of the preoperatively detected radiological transition zone in Hirschsprung’s disease

Xuyong Chen, Xiaojuan Wu, Hongyi Zhang, +4

Pediatric Surgery International

Surgical PathologyHistopathologyDiagnosisDiagnostic ValueHirschsprung ’ +3

The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation

Xuyong Chen, Lingling Liu, Siwen Kang, +2

Science Advances