Ilir Mehmeti

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

B Krümmel, Thomas Plötz, Anne Jörns et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2021 · 102 citations

Inflammation, Reductive Stress, Glutathione Peroxidase 4 +15

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity

Ilir Mehmeti, S Lortz, Edward Avezov et al. · Free Radical Biology and Medicine · 2017 · 78 citations

Gpx8 Enzyme Isoforms, Biochemistry, Medicine +10

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

Ewa Gurgul-Convey, Ilir Mehmeti, S Lortz et al. · Journal of Molecular Medicine · 2011 · 70 citations

Inflammation, Reductive Stress, Cytokine Toxicity +13

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

Ewa Gurgul-Convey, Ilir Mehmeti, Thomas Plötz et al. · Diabetologia · 2016 · 67 citations · Full text

Inflammation, Cytokine, Inflammatory Disease +11

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

Tasuku Konno, Eduardo P. Melo, Carlos Lopes et al. · The Journal of Cell Biology · 2015 · 65 citations · Full text

Disulfide Formation, Reductive Stress, Er Catalase +13