Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>

Jyoti Nangalia, Charles Massie, E. Joanna Baxter, +49

New England Journal of Medicine

An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

Joseph E. Chambers, Markéta Kubánková, Roland G. Huber, +5

ACS Nano

Biophysical ModelingEngineeringMicroscopyMolecular BiologyCytoskeleton +19

Endoplasmic Reticulum (ER) Mannosidase I Is Compartmentalized and Required for <i>N</i>-Glycan Trimming to Man_5–6GlcNAc₂ in Glycoprotein ER-associated Degradation

Edward Avezov, Zehavit Frenkel, Marcelo Ehrlich, +2

Molecular Biology of the Cell

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

Edward Avezov, Benedict C. S. Cross, Gabriele S. Kaminski Schierle, +5

The Journal of Cell Biology

Molecular BiologyDisulfide Bond FormationCellular PhysiologyRedox BiologyOxidative Stress +16

Single particle trajectories reveal active endoplasmic reticulum luminal flow

David Holcman, Pierre Parutto, Joseph E. Chambers, +6

Nature Cell Biology

Single Particle TrajectoriesEndocytic PathwaySecretory PathwayIntracellular TraffickingCellular Biochemistry +4

The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes

Meng Lü, Francesca W. van Tartwijk, Julie Qiaojin Lin, +11

Science Advances

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm

Pawan Gulati, Edward Avezov, Marcella Ma, +4

Bioscience Reports

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity

Ilir Mehmeti, S Lortz, Edward Avezov, +2

Free Radical Biology and Medicine

Gpx8 Enzyme IsoformsBiochemistryMedicineLipid PeroxidationDiabetes +8

PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress

Maria Kondratyev, Edward Avezov, Marina Shenkman, +2

Experimental Cell Research

Reductive StressProtein FunctionProtein Response MachineriesProtein FoldingMedicine +12

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

Joseph E. Chambers, Ana Crespillo-Casado, Edward Avezov, +4

eLife

Protein AssemblyMolecular BiologyTrans-protomer EngagementProtein RefoldingCellular Physiology +19