Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties

Kinga Sałat, Adrian Podkowa, Natalia Malikowska‐Racia, +7

Neuropharmacology

Gaba TransporterMedicineVivo Active InhibitorNeurotransmitterPharmacological Agent +7

Development of an (<i>S</i>)‐1‐{2‐[Tris(4‐methoxyphenyl)methoxy]ethyl}piperidine‐3‐carboxylic acid [(<i>S</i>)‐SNAP‐5114] Carba Analogue Inhibitor for Murine γ‐Aminobutyric Acid Transporter Type 4

Jörg Pabel, Mark R. Faust, Cornelia Prehn, +4

ChemMedChem

Azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors: Synthesis, biological evaluation, and structure–activity relationship

Mark R. Faust, Georg Höfner, Jörg Pabel, +1

European Journal of Medicinal Chemistry

Structure–activity RelationshipMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +10

Asymmetric Synthesis with 6‐<i>tert</i>‐Butyl‐5‐methoxy‐6‐methyl‐3,6‐dihydro‐2<i>H</i>‐1,4‐oxazin‐2‐one as a New Chiral Glycine Equivalent: Preparation of Enantiomerically Pure α‐Tertiary and α‐Quaternary α‐Amino Acids

Claus‐Jürgen Koch, Soňa Šimonyiová, Jörg Pabel, +2

European Journal of Organic Chemistry

EngineeringOrganic ChemistryPeptide ScienceChemistryStereoselective Synthesis +15

First Photoswitchable Neurotransmitter Transporter Inhibitor: Light-Induced Control of γ-Aminobutyric Acid Transporter 1 (GAT1) Activity in Mouse Brain

Gabriele Quandt, Georg Höfner, Jörg Pabel, +3

Journal of Medicinal Chemistry

Synaptic TransmissionNeurotransmitterMgat1 FunctionNeurotransmissionOptogenetics +24

Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki–Miyaura Cross‐Coupling Reactions

Marilena Petrera, Thomas Wein, Lars Allmendinger, +4

ChemMedChem

Peptide SciencePharmacotherapyNew SeriesChemical BiologyPharmaceutical Chemistry +19

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Jan Vietor, Christian Gege, Tanja Stiller, +7

Journal of Medicinal Chemistry

Neurochemical BiomarkersPharmacotherapyBiomedical EngineeringNurr1 ActivationExperimental Pharmacology +16

Generation of chiral N-acylpyridinium ions by means of silyl triflates and their diastereoselective trapping reactions: formation of N-acyldihydropyridines and N-acyldihydropyridones

Cornelia E. Hoesl, Markus Maurus, Jörg Pabel, +1

Tetrahedron

EngineeringChiral N-acylpyridinium IonsSilyl TriflatesOrganic ChemistryDiastereoselective Trapping Reactions +6

Generation of <i>N</i>-Acylpyridinium Ions from Pivaloyl Chloride and Pyridine Derivatives by Means of Silyl Triflates

Jörg Pabel, Cornelia E. Hösl, Markus Maurus, +2

The Journal of Organic Chemistry

Inorganic ChemistryChemical EngineeringPyridine DerivativesEngineeringSilyl Triflates†j +9

Automated design of multi-target ligands by generative deep learning

Laura Isigkeit, Tim Hörmann, Espen Schallmayer, +9

Nature Communications

EngineeringDe Novo Drug DesignRational Drug DesignAutomated DesignMolecular Design +4