Kevin R. Criscione

Effect of Ring Size or an Additional Heteroatom on the Potency and Selectivity of Bicyclic Benzylamine-Type Inhibitors of Phenylethanolamine<i>N</i>-Methyltransferase^1a

Gary L. Grunewald, Vilas H. Dahanukar, Piao Ching et al. · Journal of Medicinal Chemistry · 1996 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine<i>N</i>-Methyltransferase:  Balancing p<i>K</i>_aand Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination

Gary L. Grunewald, Mitchell R. Seim, Jian Lü et al. · Journal of Medicinal Chemistry · 2006 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

Nyssa Drinkwater, Hoan Vu, Kimberly M. Lovell et al. · Biochemical Journal · 2010 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and Biochemical Evaluation of 3-Fluoromethyl-1,2,3,4-tetrahydroisoquinolines as Selective Inhibitors of Phenylethanolamine <i>N</i>-Methyltransferase versus the α₂-Adrenoceptor

Gary L. Grunewald, Timothy M. Caldwell, Qifang Li et al. · Journal of Medicinal Chemistry · 1999 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine<i>N</i>-Methyltransferase

Gary L. Grunewald, Mitchell R. Seim, R.C. Regier et al. · Journal of Medicinal Chemistry · 2006 · 41 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16