Mitchell R. Seim

Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine<i>N</i>-Methyltransferase:  Balancing p<i>K</i>_aand Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination

Gary L. Grunewald, Mitchell R. Seim, Jian Lü et al. · Journal of Medicinal Chemistry · 2006 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine<i>N</i>-Methyltransferase

Gary L. Grunewald, Mitchell R. Seim, R.C. Regier et al. · Journal of Medicinal Chemistry · 2006 · 41 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase

Gary L. Grunewald, Mitchell R. Seim, Seema R. Bhat et al. · Bioorganic & Medicinal Chemistry · 2007 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11