Loïc Roux

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

Julia F. Alterman, Bruno M.D.C. Godinho, Matthew Hassler et al. · Nature Biotechnology · 2019 · 220 citations

Molecular Neuroscience, Signal Transduction, Medicine +10

RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Anton A. Turanov, Agnes S. Lo, Matthew Hassler et al. · Nature Biotechnology · 2018 · 182 citations

Developmental Biology, Genetics, Rnai Modulation +11

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Matthew Hassler, Anton A. Turanov, Julia F. Alterman et al. · Nucleic Acids Research · 2018 · 175 citations · Full text

Gene Delivery, Biomedical Engineering, Chemically-modified Sirna +17

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Maire F. Osborn, Andrew H. Coles, Annabelle Biscans et al. · Nucleic Acids Research · 2018 · 131 citations · Full text

Sirna Internalization, Proteinlipid Interaction, Lipid-conjugated Sirnas +16

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

Reka A. Haraszti, Loïc Roux, Andrew H. Coles et al. · Nucleic Acids Research · 2017 · 122 citations · Full text

Tissue Engineering, Molecular Biology, 5΄-Vinylphosphonate Improves +18