Pepijn M. Schoonen

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Pepijn M. Schoonen, Francien Talens, Colin Stok et al. · Nature Communications · 2017 · 103 citations · Full text

Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability

Rutger C.C. Hengeveld, H. Rudolf de Boer, Pepijn M. Schoonen et al. · Developmental Cell · 2015 · 97 citations · Full text

Chromatin, Genome Instability, Dna Sequencing +9

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen et al. · Oncogenesis · 2020 · 92 citations · Full text

ATR inhibition preferentially targets homologous recombination-deficient tumor cells

Małgorzata Krajewska, Rudolf S.N. Fehrmann, Pepijn M. Schoonen et al. · Oncogene · 2014 · 88 citations · Full text

Medicine, Atr Inhibition, Tumor Suppressor +4

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells

Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga et al. · Molecular Oncology · 2019 · 82 citations · Full text

Cell Death, Cancer Biology, Tumor Biology +17