Concepedia

Author

James Fossetta

Merck & Co., Inc., Rahway, NJ, USA (United States)

Also Known As

J. Fossetta, James D. Fossetta, James Fossetta

29

Publications

1.3K

Citations

17

H-Index

33

Concepts

All Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)Bloomfield CollegeUnited States Pharmacopeial ConventionInflammation Research Foundation
JF

About

James Fossetta is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in medicine, drug discovery, and pharmacology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

13

15

871

2

Biochemistry

8

8

697

3

Natural Sciences

7

7

680

4

Biomolecular Engineering

1

1

14

5

Cell Biology

1

1

18

James Fossetta

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23

Publications

1.2K

Citations

17

H-Index

YearCitations

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

Thierry Fischmann, Alan Hruza, Xiao Da Niu,

Nature Structural Biology

1999

452

Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist

Waldemar Gonsiorek, Xuedong Fan, David Hesk,

Journal of Pharmacology and Experimental Therapeutics

2007

127

Discovery of 2-Hydroxy-<i>N</i>,<i>N</i>-dimethyl-3-{2-[[(<i>R</i>)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist

Michael P. Dwyer, Younong Yu, Jianping Chao,

Journal of Medicinal Chemistry

2006

113

The carboxyl-terminal region of human interferon γ is important for biological activity: mutagenic and NMR analysis

Daniel Lundell, Charles A. Lunn, David C. Dalgarno,

Protein Engineering Design and Selection

1991

67

Pharmacological Analysis of Calcium Responses Mediated by the Human A3 Adenosine Receptor in Monocyte-Derived Dendritic Cells and Recombinant Cells

James Fossetta, James Jackson, Gregory Deno,

Molecular Pharmacology

2003

63

Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors

Ashwin U. Rao, Dong Xiao, Xianhai Huang,

Bioorganic & Medicinal Chemistry Letters

2011

56

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

William T. McElroy, Zheng Tan, Ginny D. Ho,

ACS Medicinal Chemistry Letters

2015

40

Expression of human inducible nitric oxide synthase in <i>Escherichia coli</i>

James Fossetta, Xiao Da Niu, Charles A. Lunn,

FEBS Letters

1996

37

Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336

Waldemar Gonsiorek, David Hesk, Shu‐Cheng Chen,

Journal of Biological Chemistry

2006

30

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

W. Michael Seganish, Thierry Fischmann, Brad Sherborne,

ACS Medicinal Chemistry Letters

2015

27

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