Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

Jing Tan, Xiaojing Yang, Li Zhuang, +7

Genes & Development

IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer

L.S. Ong, Wee Chyan Lee, Shijun Ma, +16

Proceedings of the National Academy of Sciences

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

Yen-An Tang, Yu-feng Chen, Bao Yi, +12

Proceedings of the National Academy of Sciences

DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in Colorectal Cancer and Is a Therapeutic Target of Histone Modifications

Xia Jiang, Jing Tan, Jingsong Li, +9

Cancer Cell

Histone ModificationsCancer ResearchTranscriptional RegulationSystems BiologyOncology +10

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

Zhen Ning Wee, Siti Maryam J. M. Yatim, Vera Kohlbauer, +13

Nature Communications

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence

Jian Yuan Goh, Min Feng, Wenyu Wang, +19

Nature Medicine

ChromatinSystems BiologyBreast Cancer RecurrenceEngineeringBreast Oncology +12

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

Shijun Ma, Yue Zhao, Wee Chyan Lee, +16

Nature Communications

Breast OncologyImmunologyImmune RegulationImmunotherapyCancer Biology +20

PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy

Jing Tan, Zhimei Li, Puay Leng Lee, +10

Cancer Discovery

B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer

Jing Tan, Puay Leng Lee, Zhimei Li, +4

Cancer Cell

Cancer ResearchSignal TransductionSignaling PathwayMedicineReceptor Tyrosine Kinase +8

A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines

Ying Chen, N. Davidson, Yuk Kei Wan, +42

EngineeringDifferent IsoformsIndividual IsoformsGeneticsMolecular Biology +22