Induction of the synthesis of tumor necrosis factor receptors by interferon-<i>gamma</i>.

Vito Ruggiero, Jan Tavernier, Walter Fiers, +1

The Journal of Immunology

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

Maria Loiarro, Federica Capolunghi, Nicola Fantò, +8

Journal of Leukocyte Biology

Affect HomodimerizationImmunologyMolecular BiologyImmunologic MechanismInflammation +16

Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-κB

Maria Loiarro, Claudio Sette, Grazia Gallo, +5

Journal of Biological Chemistry

Cytostatic and cytotoxic activity of tumor necrosis factor on human cancer cells.

Vito Ruggiero, Kathryn M. Latham, Corrado Baglioni

The Journal of Immunology

ApoptosisImmunologyPathologyCell DeathHuman Bt-20 Breast +18

Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.

Vito Ruggiero, Corrado Baglioni

The Journal of Immunology

InflammationCytokineTumor Necrosis FactorAnti-inflammatoryImmune Regulation +6

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

Federica Capolunghi, Maria Manuela Rosado, Simona Cascioli, +14

Lara D. Veeken

Identification of Critical Residues of the MyD88 Death Domain Involved in the Recruitment of Downstream Kinases

Maria Loiarro, Grazia Gallo, Nicola Fantò, +4

Journal of Biological Chemistry

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

Vito Ruggiero, Susan E. Johnson, Corrado Baglioni

Cellular Immunology

Protease InhibitorsInflammationMedicineApoptosisImmunology +4

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

Maria Loiarro, Elisabetta Volpe, Vito Ruggiero, +5

Journal of Biological Chemistry

Design, Synthesis, and In Vitro Activity of Peptidomimetic Inhibitors of Myeloid Differentiation Factor 88

Nicola Fantò, Grazia Gallo, Andrea Ciacci, +11

Journal of Medicinal Chemistry

Innate Immune SystemImmunologyPharmacotherapyInnate ImmunityImmunotherapy +20