Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

Justine D. Miller, Yosif Ganat, Sarah Kishinevsky, +14

Cell stem cell

Human Ipsc-based ModelingAgingDisease ProgressionLongevityMedicine +3

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Faranak Fattahi, Julius A. Steinbeck, Sonja Kriks, +12

Nature

Human CellCell LineageCell TherapyMedicineMolecular Biology +5

The epichaperome is an integrated chaperome network that facilitates tumour survival

Anna Rodina, Tai Wang, Pengrong Yan, +40

Nature

Tumor BiologyMedicineNatural SciencesPathologyCancer Genomics +8

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Sun Young Chung, Sarah Kishinevsky, Joseph R. Mazzulli, +11

Stem Cell Reports

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Julius A. Steinbeck, Manoj Kumar Jaiswal, Elizabeth L. Calder, +5

Cell stem cell

Human Neuromuscular DiseaseNeurophysiologyComputational NeuroscienceNeurological FunctionFunctional Connectivity +10

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

Maria Carmen Inda, Suhasini Joshi, Tai Wang, +36

Nature Communications

NeuropsychologyOptimal FunctioningNeurochemical BiomarkersToxic Hippocampal StressSocial Sciences +19

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Sarah Kishinevsky, Tai Wang, Anna Rodina, +26

Nature Communications

Behavioral characterization of cereblon forebrain-specific conditional null mice: A model for human non-syndromic intellectual disability

Anjali M. Rajadhyaksha, Stephen Ra, Sarah Kishinevsky, +11

Behavioural Brain Research

Behavioral CharacterizationNeuropsychologyMolecular NeuroscienceBrain FunctionNeurological Function +5

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Tony Taldone, Anna Rodina, Erica M. Gomes, +7

Beilstein Journal of Organic Chemistry

Biotinylated Hsp90 ProbeMolecular CharacterizationProtein FunctionTumor Hsp90 ProbesMolecular Biological Method +11