NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

Jason Tchieu, Elizabeth L. Calder, Sudha R. Guttikonda, +5

Nature Biotechnology

Induced Pluripotent Stem CellNeuroregenerationDevelopmental BiologyEpendymaGlioma +9

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Qiuying Chen, Kathryne Kirk, Yevgeniya I. Shurubor, +12

Cell Metabolism

Glutamine MetabolismBiochemistryMitochondrial FunctionBioenergetic AdaptationGenetics +10

Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment

Yosif Ganat, Elizabeth L. Calder, Sonja Kriks, +9

Journal of Clinical Investigation

Midbrain DopaminergicStem Cell MigrationStem Cell BiologyCellular NeurobiologySocial Sciences +20

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Julius A. Steinbeck, Manoj Kumar Jaiswal, Elizabeth L. Calder, +5

Cell stem cell

Human Neuromuscular DiseaseNeurophysiologyComputational NeuroscienceNeurological FunctionFunctional Connectivity +10

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons

Emiliano Hergenreder, Andrew P. Minotti, Yana Zorina, +12

Nature Biotechnology

Brain DevelopmentAdult Stem CellStem Cell BiologySynaptic SignalingSocial Sciences +21

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy

Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, +19

Cell stem cell

Schwann CellsPeripheral NervePeripheral NervesDiabetic NeuropathyNeurology +14

Receptor Regulation of Gene Expression of Axon Guidance Molecules: Implications for Adaptation

Amy K Jassen, Hong Yang, Gregory M. Miller, +2

Molecular Pharmacology

Retinoic Acid-Mediated Regulation of <i>GLI3</i> Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

Elizabeth L. Calder, Jason Tchieu, Julius A. Steinbeck, +8

Journal of Neuroscience

Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons

Emiliano Hergenreder, Yana Zorina, Zeping Zhao, +11

Brain DevelopmentSmall Molecule TreatmentAdult Stem CellCerebral OrganoidStem Cell Biology +21

Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients

Qiuying Chen, Csaba Konràd, Davinder Sandhu, +10

Neurobiology of Disease