Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease

Emna Maalej, Fakher Chabchoub, María Jesús Oset‐Gasque, +12

European Journal of Medicinal Chemistry

Medicinal ChemistryPotential DrugsBiochemistryNatural SciencesMedicine +7

Synthesis and antigenotoxic activity of some naphtho[2,1-b]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives

Fakher Chabchoub, Mehdi Messaâd, Hédi Ben Mansour, +2

European Journal of Medicinal Chemistry

Bioorganic ChemistryBiochemistryNatural SciencesHeterocycle ChemistryPharmacology +2

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

R.S. Malek, Raquel L. Arribas, Alejandra Palomino‐Antolín, +19

Journal of Medicinal Chemistry

Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy

Youssef Dgachi, Olga Sokolov, Vincent Luzet, +14

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseDisease TherapyBiochemistryMedicine +10

Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer’s disease therapy

R.S. Malek, Maciej Maj, Artur Wnorowski, +7

Bioorganic Chemistry

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseMedicineMulti-target 1,4-Dihydropyridines +8

Nontoxic and Neuroprotective β-Naphthotacrines for Alzheimer’s Disease

Mario Esquivias-Pérez, Emna Maalej, Alejandro Romero, +4

Chemical Research in Toxicology

Cellular PharmacologyExperimental PharmacologyPharmaceutical ChemistryNeuroprotective β-NaphthotacrinesPre-clinical Pharmacology +16

Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multicomponent reaction toward 5-amino-1-phenyl[1,2,4]triazole derivatives

Monia Aouali, Dhekra Mhalla, Fatma Allouche, +4

Medicinal Chemistry Research

Derivative (Chemistry)Organic ChemistryAntioxidant ActivitiesNew Multicomponent ReactionPharmacology +1

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

Youssef Dgachi, Óscar M. Bautista‐Aguilera, Mohamed Benchekroun, +12

Molecules

Alzheimer ’Pharmaceutical ChemistryOxidative StressMolecular PharmacologyMedicinal Chemistry +17

Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms

Fatma Allouche, Fakher Chabchoub, Fabrizio Carta, +1

Journal of Enzyme Inhibition and Medicinal Chemistry

Combinatorial ChemistryConvenient ProtocolBiochemistryMedicineHydrazine Derivatives +10

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ₁₋₄₂ Aggregation Inhibitors for Alzheimer's Disease Therapy

Youssef Dgachi, Lhassane Ismaïli, Damijan Knez, +13

ChemMedChem

Disease TherapyOrganic ChemistryPharmaceutical ChemistryDiversity Oriented SynthesisRacemic Benzochromenopyrimidinimines +18