U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Diane Lefaudeux, Bertrand De Meulder, Matthew J. Loza, +217

Journal of Allergy and Clinical Immunology

AsthmaAllergySputum OmicsMulti-omics StudyImmunology +7

IL-17–high asthma with features of a psoriasis immunophenotype

Jörgen Östling, Marleen van Geest, James Schofield, +279

Journal of Allergy and Clinical Immunology

AsthmaAllergyImmunologyIl-17–high AsthmaMedicine +1

TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation

Michelle A. Hardyman, Emily Wilkinson, Emma C. Martin, +8

Journal of Allergy and Clinical Immunology

The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

B. Hughes, D. Howat, H. Lisle, +22

British Journal of Pharmacology

InflammationMolecular PharmacologyPotent Pde 4Pleural EosinophiliaAllergy +10

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, +6

PLoS ONE

InflammationAsthmaGene Expression ResponseInflammatory Lung DiseaseAllergy +13

CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors

Rakki P. Alexander, Graham J. Warrellow, Michael A. W. Eaton, +22

Bioorganic & Medicinal Chemistry Letters

A PrototypeMedicineImmunologyPharmacological AgentPharmacotherapy +6

Capsaicin pre-treatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits

Caroline M. Herd, Neil Gozzard, Clive Page

European Journal of Pharmacology

InflammationInflammatory Lung DiseaseLung InflammationCapsaicin Pre-treatment PreventsImmunology +5

Inhibition of bronchospasm and ozone‐induced airway hyperresponsiveness in the guinea‐pig by CDP840, a novel phosphodiesterase type 4 inhibitor

Mark Holbrook, Neil Gozzard, T.J. James, +2

British Journal of Pharmacology

AsthmaPharmaceutical ScienceInflammatory Lung DiseaseLung InflammationPharmacotherapy +14

Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen‐induced airway responses in neonatally immunised rabbits

Neil Gozzard, Ahmed Z. El‐Hashim, Caroline M. Herd, +5

British Journal of Pharmacology

Effects of theophylline and rolipram on antigen‐induced airway responses in neonatally immunized rabbits

Neil Gozzard, Caroline M. Herd, Sophia M. Blake, +4

British Journal of Pharmacology