Concepedia

TNF-α–mediated bronchial barrier disruption and regulation by src-family kinase activation

Michelle A. Hardyman, Emily Wilkinson, Emma C. Martin, Nivenka Jayasekera, Cornelia Blume, Emily J. Swindle, Neil Gozzard, Stephen T. Holgate, Peter Howarth, Donna E. Davies,

Journal of Allergy and Clinical Immunology · 2013 · 114 citations · 47 references

DOIFull text

Open access

Abstract

Inhibiting TNF-α or src kinases may be a therapeutic option to normalize barrier integrity and cytokine release in airway diseases associated with barrier dysfunction.

References

47

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

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, , +12

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Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

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SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

Robert A. Blake, Martin A. Broome, Xiangdong Liu et al. · Molecular and Cellular Biology · 2000 · 583 citations · Full text