N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

Étienne Dardenne, Himisha Beltran, Matteo Benelli, +18

Cancer Cell

Transcriptional RegulationMedicineCell BiologyProstatic DiseaseOncology +3

A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials

Kaitlyn Gayvert, Neel S. Madhukar, Olivier Elemento

Cell chemical biology

Clinical Trial DesignClinical Trial ManagementReal World EvidenceClinical EndpointStatistics +11

A Bayesian machine learning approach for drug target identification using diverse data types

Neel S. Madhukar, Prashant K. Khade, Linda Huang, +6

Nature Communications

Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape

Nora C. Pyenson, Kaitlyn Gayvert, Andrew Varble, +2

Cell Host & Microbe

PathogenesisImmunologyVirologyGene EditingGenome Editing +5

A Computational Approach for Identifying Synergistic Drug Combinations

Kaitlyn Gayvert, Omar M. Aly, James T. Platt, +3

PLoS Computational Biology

Drug TargetComputational ApproachTumor BiologyDrug ResistanceMedicinal Chemistry +15

ENCAPP: elastic-net-based prognosis prediction and biomarker discovery for human cancers

Jishnu Das, Kaitlyn Gayvert, Florentina Bunea, +2

BMC Genomics

A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors

Kaitlyn Gayvert, Étienne Dardenne, Cynthia Cheung, +8

Cell Reports

Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy

Matthew F. Wipperman, Kaitlyn Gayvert, Amanda Atanasio, +15

Allergy

A New Big-Data Paradigm for Target Identification and Drug Discovery

Neel S. Madhukar, Prashant K. Khade, Linda Huang, +6

Drug TargetEngineeringHit IdentificationTarget Identification PlatformTarget Identification +19

Blocking common γ chain cytokine signaling ameliorates T cell–mediated pathogenesis in disease models

Audrey Le Floc’h, Kirsten Nagashima, Dylan Birchard, +26

Science Translational Medicine